Paul Cairns, PhD

Member
Medical Science Division


Paul.Cairns@fccc.edu
Phone: 215-728-5635
Paul Cairns, PhD


Recent Publications


In Press


Ibanez de Caceres, I., Dulaimi, E., Hoffman, A.M., Al-Saleen, T., Uzzo, R.G., Cairns, P. Identification of novel target genes by an epigenetic reactivation screen of renal cancer. Cancer Res. (in press).

2004


Al-Saleem, T., Cairns, P., Dulaimi, E., Feder, M., Testa, J., Uzzo, R. The genetics of renal oncocytosis: A possible model for neoplastic progression. Cancer Genet. Cytogenet. 152:23-28, 2004.

Cairns, P. Detection of promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients. Ann. N.Y. Acad. Sci. 1022:40-43, 2004.

Cairns, P., Adams, P.D. Clipped wings: Epigenetic inactivation of APC. Cancer Biol. Ther. 3:965-966, 2004.

Dulaimi, E., Uzzo, R.G., Greenberg, R.E., Al-Saleem, T., Cairns, P. Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel. Clin. Cancer Res. 10:1887-1893, 2004.

Dulaimi, E., Hillinck, J., Ibanez, I. Cairns, P. Tumor suppressor gene promoter hypermethylation in serum from breast cancer patients. Clin. Cancer Res. 10:6189-6193, 2004.

Dulaimi, E., Ibanez, I., Uzzo, R.G., Al-Saleem, T., Greenberg, R.E., Polasik, T., Babb, J., Grizzle, W., Cairns, P. Promoter hypermethylation of kidney cancer. Clin. Cancer. Res. 10:3972-3979, 2004.

Ibanez de Caceres, I., Frolova, N., Varkonyi, R., Dulaimi, E. Meropol, N.J., Broccoli, D., Cairns, P. Frequent activation of telomerase in mismatch repair deficient tumors. Cancer Biol. Ther. 3:289-292, 2004.

Ibanez de Caceres, I., Battagli, C., Esteller, M., Herman, J., Dulaimi, E., Edelson, M.I., Bergman, C., Ehya, H., Eisenberg, B.L., Cairns, P. Tumor cell specific BRCA1 and RASSF1A hypermethylation in serum, plasma and peritoneal fluid from ovarian cancer patients. Cancer Res. 64:6476-6481, 2004.

Krassenstein, R., Sauter, E., Dulaimi, E. Battagli, C., Ehya, H., Klein-Szanto, A., Cairns, P. Detection of breast cancer in nipple aspirate fluid by hypermethylation. Clin. Cancer Res. 10:28-32, 2004.

Sauter, G., Knowles, M.,Waldman, F., Sidransky, D., Cordon-Cardo, C. Jones, P., Cairns, P. Pathology and genetics of tumours of the urinary system. In WHO Classification Tumors of the Urinary System, edited by J. Eble, G. Sauter, J. Epstein, I. Sesterhenn. IARC, pp. 89-154, 2004.

2003


Abdollahi, A., Pisarcik, D., Roberts, D., Weinstein, J., Cairns, P., Hamilton, T.C. LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer. J. Biol. Chem. 278:6041-6049, 2003.

Adams, P.D., Cairns, P. Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cells. Cancer Biol. Ther. 2:557-558, 2003.

Battagli, C., Uzzo, R., Dulaimi, E., Krassenstein, R., Al-Saleem, T., Greenberg, R.E., Cairns, P. Tumor suppressor gene hypermethylation in urine DNA from kidney cancer patients. Cancer Res. 63:8695-8699, 2003.

Hoque, M.O., Lee, C-C.R., Cairns, P., Schoenberg, M., Sidransky, D. Genome-wide genetic characterization of bladder cancer: A comparison of high-density single-nucleotide polymorphism arrays and PCR-based microsatellite analysis. Cancer Res. 63:2216-22, 2003.

Prowse, A., Schultz, D.C., Guo, S., Vanderveer, L., Dangel, J. Bove, B., Cairns, P., Daly, M., Godwin, A.K. Identification of a novel splice acceptor site mutation in p16INK4A/p14ARF within a breast cancer, melanoma, neurofibroma-prone kindred. J. Med. Genet. 40:(8)102-108, 2003.

Uzzo, R.G., Cairns, P., Al-Saleem, T., Hudes, G., Haas, N., Greenberg, R.E., Kolenko, V. The basic biology and immunobiology of renal cell carcinoma: Considerations for the clinician. Urol. Clin. N. Am. 30:423-426, 2003.

2002


Cairns, P., Sidransky, D. Bladder Cancer, Chapter 44. In The Genetic Basis of Human Cancer, Second Edition, edited by B. Vogelstein and K. Kinzler. McGraw-Hill Inc., 2002.

Polascik, T.J., Bostwick, D.G., Cairns, P. Molecular genetics and histopathologic features of adult distal nephron tumors. Urology 60:941-946, 2002.

Waldman, F.M., Jones, P.A., Knowles, M.A., Sidransky, D., Cordon-Cardo, C., Simon, R., Cairns, P. Pathology and genetics of tumors of the urinary system and male genital organs. In WHO Classification of Tumors, 2002.

2001


Cairns, P., Esteller, M., Herman, J.G., Schoenberg, M., Jeronimo, C., Sanchez-Cespedes, M., Chow, N-H., Grasso, M., Wu, L., Westra, W.B., Sidransky, D. Molecular detection of prostate cancer in urine by GSTP1 hypermethylation. Clin. Cancer Res. 7:2727-2730, 2001.

Cairns, P., Sidransky, D. Bladder Cancer, Chapter 54. In Metabolic and Molecular Basis of Inherited Disease, edited by C.R. Scriver, et al. McGraw-Hill Inc., pp. 1113-1118, 2001.