Jonathan Chernoff, MD, PhD

Senior Member
Basic Science Division


Jonathan.Chernoff@fccc.edu
Phone: 215-728-5319
Jonathan Chernoff, MD, PhD


Recent Publications

2006

Dadke S, Cotteret S, Yip SC, Jaffer ZM, Haj F, Ivanov A, Rauscher F 3rd, Shuai K, Ng T, Neel BG, Chernoff J.  Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol. 2007 Jan;9(1):80-85. Epub 2006 Dec 10.

PMID: 17159996 [PubMed - as supplied by publisher]

 

Thullberg M, Gad A, Beeser A, Chernoff J, Stromblad S.  The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity. Oncogene. 2006 Sep 25; [Epub ahead of print]

PMID: 17001318 [PubMed - as supplied by publisher]

 

Peterson JR, Chernoff J.  Src transforms in a Cool way. Nat Cell Biol. 2006 Sep;8(9):905-7. No abstract available.

PMID: 16946737 [PubMed - indexed for MEDLINE]

 

Pirruccello M, Sondermann H, Pelton JG, Pellicena P, Hoelz A, Chernoff J, Wemmer DE, Kuriyan J.  A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol. 2006 Aug 11;361(2):312-26. Epub 2006 Jun 27. PMID: 16837009 [PubMed - indexed for MEDLINE]

 

Cotteret S, Chernoff J.  Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties. Mol Cell Biol. 2006 Apr;26(8):3215-30. PMID: 16581795 [PubMed - indexed for MEDLINE]

 

ten Klooster JP, Jaffer ZM, Chernoff J, Hordijk PL.  Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol. 2006 Feb 27;172(5):759-69. Epub 2006 Feb 21. PMID: 16492808 [PubMed - indexed for MEDLINE]

 

2005

Bartholomew PJ, Jones CW, Benware A, Chernoff J, LaFlamme SE.  Regulation of the catalytic activity of PTP1B: roles for cell adhesion, tyrosine residue 66, and proline residues 309 and 310. Exp Cell Res. 2005 Dec 10;311(2):294-306. Epub 2005 Nov 11. PMID: 16289152 [PubMed - indexed for MEDLINE]

 

Beeser A, Chernoff J. Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction. Methods. 2005 Oct;37(2):203-7. PMID: 16288885 [PubMed - indexed for MEDLINE]

 

Li S, Depetris RS, Barford D, Chernoff J, Hubbard SR.  Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase. Structure. 2005 Nov;13(11):1643-51. PMID: 16271887 [PubMed - in process]

 

Cotteret S, Chernoff J.  Pak GITs to Aurora-A. Dev Cell. 2005 Nov;9(5):573-4. Review. PMID: 16256730 [PubMed - indexed for MEDLINE]

 

Beeser A, Jaffer ZM, Hofmann C, Chernoff J.  Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J Biol Chem. 2005 Nov 4;280(44):36609-15. Epub 2005 Aug 29. PMID: 16129686 [PubMed - indexed for MEDLINE]

 

Leisner TM, Liu M, Jaffer ZM, Chernoff J, Parise LV.  Essential role of CIB1 in regulating PAK1 activation and cell migration. J Cell Biol. 2005 Aug 1;170(3):465-76. PMID: 16061695 [PubMed - indexed for MEDLINE]

 

Gonzalez Guerrico AM, Jaffer ZM, Page RE, Braunewell KH, Chernoff J, Klein-Szanto AJ.  Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene. 2005 Mar 31;24(14):2307-16.

PMID: 15735716 [PubMed - indexed for MEDLINE]

 

Parsons M, Monypenny J, Ameer-Beg SM, Millard TH, Machesky LM, Peter M, Keppler MD, Schiavo G, Watson R, Chernoff J, Zicha D, Vojnovic B, Ng T.  Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol Cell Biol. 2005 Mar;25(5):1680-95. PMID: 15713627 [PubMed - indexed for MEDLINE]

 

Sorokina EM, Chernoff J.  Rho-GTPases: new members, new pathways. J Cell Biochem. 2005 Feb 1;94(2):225-31. Review.

PMID: 15543593 [PubMed - indexed for MEDLINE]

 

Chernoff J STK4 (serine/threonine kinase 4). Atlas Genet Cytogenet Oncol Haematol. November 2005. URL: http://AtlasGeneticsOncology.org/Genes/STK4ID42440ch20q11.html

2004

 

Hofmann C, Shepelev M, Chernoff J.  The genetics of Pak. J Cell Sci. 2004 Sep 1;117(Pt 19):4343-54. Review.

PMID: 15331659 [PubMed - indexed for MEDLINE]

 

Jaffer ZM, Chernoff J.  The cross-Rho'ds of cell-cell adhesion. J Biol Chem. 2004 Aug 20;279(34):35123-6. Epub 2004 May 7. Review. No abstract available. PMID: 15133033 [PubMed - indexed for MEDLINE]

 

Reynolds LF, de Bettignies C, Norton T, Beeser A, Chernoff J, Tybulewicz VL.  Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem. 2004 Apr 30;279(18):18239-46. Epub 2004 Feb 5. PMID: 14764585 [PubMed - indexed for MEDLINE]

 

Golemis EA, Chernoff J.  Analysis and manipulation of intracellular signaling cascades. Methods. 2004 Apr;32(4):347-8. No abstract available. PMID: 15003596 [PubMed - indexed for MEDLINE]

2003

 

Dadke S, Chernoff J.  Protein-tyrosine phosphatase 1B as a potential drug target for obesity. Curr Drug Targets Immune Endocr Metabol Disord. 2003 Dec;3(4):299-304. Review. PMID: 14683461 [PubMed - indexed for MEDLINE]

 

Xiao GH, Chernoff J, Testa JR.  NF2: the wizardry of merlin. Genes Chromosomes Cancer. 2003 Dec;38(4):389-99. Review.

PMID: 14566860 [PubMed - indexed for MEDLINE]

 

Dadke S, Chernoff J.  Protein-tyrosine phosphatase 1B mediates the effects of insulin on the actin cytoskeleton in immortalized fibroblasts. J Biol Chem. 2003 Oct 17;278(42):40607-11. Epub 2003 Aug 5. PMID: 12902327 [PubMed - indexed for MEDLINE]

 

Cai D, Iyer A, Felekkis KN, Near RI, Luo Z, Chernoff J, Albanese C, Pestell RG, Lerner A.  AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res. 2003 Oct 15;63(20):6802-8. PMID: 14583477 [PubMed - indexed for MEDLINE]

 

Zegers MM, Forget MA, Chernoff J, Mostov KE, ter Beest MB, Hansen SH.  Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J. 2003 Aug 15;22(16):4155-65. PMID: 12912914 [PubMed - indexed for MEDLINE]

 

Cotteret S, Jaffer ZM, Beeser A, Chernoff J.  p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol. 2003 Aug;23(16):5526-39. PMID: 12897128 [PubMed - indexed for MEDLINE]

 

Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, Mizzen CA, Beeser A, Etkin LD, Chernoff J, Earnshaw WC, Allis CD.  Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell. 2003 May 16;113(4):507-17. PMID: 12757711 [PubMed - indexed for MEDLINE]

 

Deacon K, Mistry P, Chernoff J, Blank JL, Patel R.  p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest. Mol Biol Cell. 2003 May;14(5):2071-87. Epub 2003 Jan 26. PMID: 12802076 [PubMed - indexed for MEDLINE]

 

Penzes P, Beeser A, Chernoff J, Schiller MR, Eipper BA, Mains RE, Huganir RL.  Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron. 2003 Jan 23;37(2):263-74. PMID: 12546821 [PubMed - indexed for MEDLINE]

 

Beeser A, Chernoff J. Rho GTPases and cell motility. In Rho GTPases, Landes Biosciences, edited by M. Symons, pp. 141-154, 2003. ISBN: 1-58706-199-6