Yeager, N., Klein-Szanto, A., Kimura, S. and Di Cristofano, A. Pten Loss in the Mouse Thyroid Causes Goiter and Follicular Adenomas: Insights into Thyroid Function and Cowden Disease Pathogenesis. Cancer Res. 67:959-966, 2007.
Di Cristofano A. and Ellenson LH. Endometrial Carcinoma. Annu. Rev. Pathol. Mech. Dis., 2:57-85, 2007.
Vilgelm, A., Lian, Z., Wang, H., Beauparlant, S.L., Klein-Szanto, A., Ellenson, L.H. and Di Cristofano, A. Akt-Mediated Phosphorylation and Activation of ERa Is Required for Endometrial Neoplastic Transformation in Pten+/- Mice. Cancer Res., 66:3375-3380, 2006.
Lian, Z., De Luca, P. and Di Cristofano, A. Gene Expression Analysis Reveals a Signature of Estrogen Receptor Activation upon Loss of Pten in a Mouse Model of Endometrial Cancer. J. Cell. Physiol. , 208:255-266, 2006.
Chen, M, Xu, P, Peng, X, Chen, WS, Guzman, G, Yang, X, Di Cristofano, A, Pandolfi, PP, and Hay, N. The deficiency of Akt1 is sufficient to inhibit tumor development in Pten+/- mice. Genes & Dev. 20:1569-1574, 2006.
Bellacosa, A., Kumar, C., Di Cristofano, A., and Testa, J.R. Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting. Adv. Cancer Res., 94: 29-86, 2005.
Wang, H.Q., Altomare, D.A., Skele, K.L., Poulikakos, P.I., Kuhajda, F.P., Di Cristofano, A. and Testa, J.R. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene, 24: 3574-3582, 2005.
Xiao A., Yin C., Yang C., Di Cristofano A., Pandolfi P.P., and Van Dyke, T. Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation. Cancer Res., 65: 5172-5180, 2005.
Pasche, B., Knobloch, T.J., Bian, Y., Liu, J., Phukan, S., Rosman, D., Kaklamani, V., Baddi, L., Frankel, W., Prior, T.W., Sculler, D.E., Agrawal, A., Lang, J., Dolan, M.E., Vokes E.E., Lane, W.S., Huang, C.C., Caldes, T., Di Cristofano, A., Hampel, H., Nilsson I., von Heijne, G., Fodde, R., Murty, V.V.V.S., de la Chapelle, A., and Weghorst, C.M. Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA, 294: 1634-1646, 2005.
Lian, Z. and Di Cristofano, A. Class reunion: PTEN joins the nuclear crew. Oncogene, 24:7394-7400, 2005.
Ferri A.L., Cavallaro M., Braida D., Di Cristofano A., Canta A., Vezzani A., Ottolenghi S., Pandolfi P.P., Sala M., DeBiasi S., and Nicolis S.K. Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development, 131: 3805-3819, 2004.
Beauparlant, S.L., Read, P.W., and Di Cristofano, A. In Vivo Adenovirus-Mediated Gene Transduction into Mouse Endometrial Glands: a Novel Tool to Model Endometrial Cancer in the Mouse. Gyn. Oncol., 94: 713-718, 2004.
Niki, M., Di Cristofano, A., Zhao, M., Honda, H., Hirai, H., Van Aelst, L., Cordon-Cardo, C., and Pandolfi, P.P. Role of Dok-1 and Dok-2 in leukemia suppression. J. Exp. Med., 200: 1689-95, 2004.
Trotman, L.C., Niki, M., Dotan, Z.A., Koutcher, J.A., Di Cristofano, A., Xiao, A., Khoo, A.S., Roy-Burman, P., Greenberg, N.M., Van Dyke, T., Cordon-Cardo, C., Pandolfi, P.P. Pten dose dictates cancer progression in the prostate. PLoS Biol. 1:E59, 2003.
Kandel E.S., Skeen J., Majewski N., Di Cristofano A., Pandolfi P.P., Feliciano C.S., Gartel A., Hay N. Activation of Akt/protein kinase B overcomes a G(2)/M cell cycle checkpoint induced by DNA damage. Mol. Cell. Biol. 22:7831-7841, 2002.
Kim S., Domon-Dell C., Wang Q., Chung DH., Di Cristofano, A., Pandolfi, P.P., Freund, J.N., Evers, B.M. PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappa B-dependent pathway. Gastroenterology 123:1163-78, 2002.
Lacorazza, H.D., Miyazaki, Y., Di Cristofano, A., Deblasio, A., Hedvat, C., Zhang, J., Cordon-Cardo, C., Mao, S., Pandolfi, P.P., Nimer, S.D. The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells. Immunity 17:437-449, 2002.
Li, L., Liu, F., Salmonsen, R.A., Turner, T.K., Litofsky, N.S., Di Cristofano, A., Pandolfi, P.P., Jones, S.N., Recht, L.D., Ross, A.H. PTEN in neural precursor cells: Regulation of migration, apoptosis and proliferation. Mol. Cell. Neurosci. 20:21-29, 2002.
Parisi, T., Pollice, A., Di Cristofano, A., Calabro, V., La Mantia, G. Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors. Biochem. Biophys. Res. Commun. 291:1138-1145, 2002.
Di Cristofano, A., De Acetis, M., Koff, A., Cordon-Cardo, C. and Pandolfi, P.P. Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nat. Genet., 27: 222-224, 2001.
Di Cristofano, A., Niki, M., Zhao, M., Karnell, F.G., Clarkson, B., Pear, W.S., Van Aelst, L. and Pandolfi, P.P. p62dok, a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210bcr-abl. J. Exp. Med., 194: 275-284, 2001.
Svensson, A.C., Raudsepp, T., Larsson, C., Di Cristofano, A., Chowdhary, B., La Mantia, G., Rask, L. and Andersson, G. Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9. Cytogenet. Cell Genet., 92: 89-96, 2001.
Zhao, M., Schmitz, A.A., Qin, Y., Di Cristofano, A., Pandolfi, P.P. and Van Aelst, L. PI3-kinase dependent membrane recruitment of p62dok is essential for its negative effect on MAP-kinase activation. J. Exp. Med., 194: 265-274, 2001.