Page, R.E., Klein-Szanto, A.J.P., Litwin, S., Nicolas, E., Al-Jumaily, R., Alexander, P., Godwin, A.K., Ross, E.A., Schilder, R.J., Bassi, D.E. Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer. Cell Oncol. (in press).
Posadas, E.M., Liel, M.S., Kwitkowski, V., Minasian, L., Godwin, A.K., Hussain, M.M., Espina, V., Wood, B.J., Steinberg, S.M., Kohn, E.C. A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer. Cancer 2007 Mar 1; [Epub ahead of print] PMID: 17330838.
Li, H., Cherukuri, P., Li, N., Cowling, V., Spinella, M., Cole, M., Godwin, A.K., Wells, W., DiRenzo, J. Nestin is expressed in the basal/myoepithelial layer of the mammary gland and is a selective marker of basal epithelial breast tumors. Cancer Res. 67:501-510, 2007.
Bane, A.l., Beck, J.C., Bleiweiss, I., Buys, S.S., Catalano, E., Daly, M.B., Giles, G., Godwin, A.K., Hisbshoosh, H., Hopper, J.L., John, E.M., Layfield, L., Longacre, T., Miron, A., Senie, R., Southey, M.C., West, D.W., Whittemore, A.S., Wu, H., Andrulis, I.L., O’Malley, F.P. BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarrays. Am. J. Surg. Pathol. 31:121-128, 2007.
Cai, K.Q., Yang, W-L., Capo-Chichi, C.D., Vanderveer, L., Wu, H., Godwin, A.K., Xu, X-X. Prominent expression of metalloproteinases in early stages of ovarian tumorigenesis. Mol. Carcinog. 46:130-143, 2007.
Petrocca, F., Ilipopoulos, D., Qin, H.R., Nicoloso, M.S., Yendamuri, S., Wojcik, S.E., Shimizu, M., Di Leva, G., Vecchione, A., Trapasso, F., Godwin, A.K., Negrini, M., Calin, G.A., Croce, C.M. Alterations of the tumor suppressor gene ARLTS1 in ovarian cancer. Cancer Res. 66:10287-10291, 2006.
Haile, R.W., Thomas, D.C., McGuire, V., Felberg, A., John, E.M., Milne, R.L., Hopper, J.L., Jenkins, M.A., Levine, A.J., Daly, M.M., Buys, S.S., Senie, R.M., Andrulis, I.L., Knight, J.A., Godwin, A.K., Southey, M., McCredie, M.R., Giles, G.G., Andrews, L., Tucker, K., Miron. A., Apicella, C., Tesoriero, A., Bane, A., Pike, M.C., kConFab Investigators; Ontario Cancer Genetics Network Investigators; Whittemore, A.S. BRCA1 and BRCA2 mutation carriers, oral contraceptive use and breast cancer before age 50. Cancer Epidemiol. Biomarkers Prev. 15:1863-1870, 2006.
Pan, Z-Z., Bruening, W., Godwin, A.K. Involvement of RHO GTPases and ERK in synuclein-gamma enhanced cancer cell motility. Int. J. Oncol. 29:1201-1205, 2006.
McGuire, V., John, E.M., Felberg, A., Haile, R.W., Boyd, N.F., Thomas, D.C., Jenkins, M.A., Milne, R.L., Daly, M.B., Ward, J., Terry, M.B., Andrulis, I.L., Knight, J.A., Godwin, A.K., Giles, G.G., kConFab Investigators, Southey, M., West, D.W., Hopper, J.L., Whittemore, A.S. No increase risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations under age 50 years. Cancer Epidemiol. Biomarkers Prev. 15:1565-1567, 2006.
Tarn, C., Skorobogatko, Y.V., Taguchi, T., Eisenberg, B., von Mehren, M., Godwin, A.K. Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms. Cancer Res. 66:5477-5486, 2006.
Chen, X., Arciero, C.A., Wang, C., Broccoli, D., Godwin, A.K. BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation. Cancer Res. 66:5039-5046, 2006.
Chen, X., Truong, T.T., Weaver, J., Bove, B.A., Cattie, K., Armstrong, B.A., Daly, M.B., Godwin, A.K. Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression. Hum. Mutat. 27:427-435, 2006.
Chen, X., Arciero, C., Godwin, A.K. BRCA1-associated complexes: new targets to overcome breast cancer radiation resistance. Exp. Rev. Anticancer Ther. 6:187-196, 2006.
Spurdle, A.B., Antoniou, A.C, Kelemen, L., Holland, H., Peock, S., Cook, M.R., Smith, P.L., Greene, M.H., Simard, J., Plourde, M., Southey, M.C., Godwin, A.K., Beck, J., Miron, A., Daly, M.B., Santella, R.M., Hopper, J.L., John, E.M., Andrulis, I.L., Durocher, F., Struewing, J.P., Easton, D.F., Chenevix-Trench, G.; ABCFS, AJBCS, BCFR, INHERIT, kConFaB, EMBRACE Study Collaborators, The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol. Biomarkers Prev. 15:76-79, 2006.
Prowse, A.H., Manek, S., Varma, R., Liu, J., Godwin, A.K., Maher, E.R., Tomlinson, I.P., Kennedy, S.H. Molecular genetic evidence that endometriosis is a precursor of ovarian cancer. Int. J. Cancer 119:556-562, 2006.
He, F., Fenner, B.J., Godwin, A.K., Kwang, J. White spot syndrome virus open reading frame 222 encodes a viral E3 ligase and mediates degradation of a host tumor suppressor via ubiquitination. J. Virol. 80:3884-3892, 2006.
Cai, K.Q., Klein-Szanto, A., Karthik D., Edelson M., Daly M.B., Ozols R.F., Lynch H.T., Godwin A.K., Xu X.X. Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations. Gynecol. Oncol. 103:719-728, 2006.
Colilla, S., Kantoff, P.W., Neuhausen, S.L., Godwin, A.K., Daly, M.B., Narod, S.A., Garber, J.E., Lynch, H.T., Brown, M., Weber, B.L., Rebbeck, T.R. The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. Carcinogenesis 27:599-605, 2006.
Azizi, A.A., Gelpi, E., Yang, J.W., Rupp, B., Godwin, A.K., Slater, C., Slavc, I., Lubec, G. Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY. Cancer Lett. 241:235-249, 2006.
Schilder, R., Sill, M.W., Chen, X., Darcy, K.M., Decesare, S.L., Lewandowski, G., Lee, R.B., Arciero, C.A., Wu, H., Godwin, A.K. Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a gynecologic oncology group study. Clin. Cancer Res. 11:5539-5548, 2005.
Tarn, C., Merkel, E., Canutescu, A., Shen, W., Skorobogatko, Y., Heslin, M.J., Eisenberg, B., Birbe, R., Patchefsky, A., Dunbrack, R., Arnoletti, J.P., von Mehren, M., Godwin, A.K. Analysis of KIT mutations in sporadic and familial gastrointestinal stromal tumors: therapeutic implications using protein modeling. Clin. Cancer Res. 11:3668-3677, 2005. (Clinical Cancer Research cover article).
Guo, S., Hakimi, M.A., Baillat, D., Chen, X., Farber, M.J., Klein-Szanto, A.J.P., Cooch, N.S., Godwin, A.K., Shiekhattar, R. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Cancer Res. 65:3011-3016, 2005. (S. Guo is under the supervision of Dr. Godwin, co-corresponding author) .
Smith-Beckerman, D.M., Fung, K.W., Williams, K.E., Auersperg, N., Godwin, A.K., Burlingame, A.L. Proteome changes in ovarian epithelial cells derived from women with BRCA-1 mutations and family histories of cancer. Mol. Cell. Proteomics 4:156-168, 2005.
Wu, H., Barusevicius, A., Babb, J., Klein-Szanto, A., Godwin, A.K., Elenitsas, R., Gelfand, J.M., Lessin, S., Seykora, J.T. Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential. J. Cutan. Pathology 32:125-130, 2005.
Sarti, M., Sevignani, C., Calin, G.A., Aqeilan, R., Shimizu, M., Pentimalli, F., Picchio, M.C., Godwin, A., Rosenberg, A., Drusco, A., Negrini, M., Croce C.M. Adenoviral transduction of TESTIN gene into breast and uterine cancer cell lines promotes apoptosis and tumor reduction in vivo. Clin Cancer Res. 11:806-13, 2005.
Calin, G.A., Trapasso, F., Shimizu, M., Dumitru, C.D., Yendamuri, S., Godwin, A.K., Ferracin, M., Bernardi, G., Chatterjee, D., Baldassarre, G., Rattan, S., Alder, H., Mabuchi, H., Shiraishi, T., Hansen, L.L., Overgaard, J., Herlea, V., Mauro, F.R., Dighiero, G., Movsas, B., Rassenti, L., Kipps, T., Baffa, R., Fusco, A., Mori, M., Russo, G., Liu, C.G., Neuberg, D., Bullrich, F., Negrini, M., Croce, C. Familial cancer associated with a polymorphism in ARLTS1. N. Engl. J. Med. 352:1167-1676, 2005.
Nunez, M.I., Rosen, D., Ludes-Meyers, J.H., Abba, M.C., Kil, H., Page, R., Klein-Szanto, A.J.P., Godwin. A.K., Liu, J., Mills, G.B. Aldaz, C.M. WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome. BMC Cancer 5:64, 2005.
Yang, W.L., Roland, I.H. Godwin, A.K. Xu. X.X. Loss of TNF-alpha-regulated COX-2 expression in ovarian cancer cells. Oncogene 24:7991-8002, 2005.
Capo-Chichi, C.D., Rula, M.E., Smedberg, J., Vanderveer, L., Parmacek, M.S., Morrisey, E.E., Godwin, A.K., Xu, X.X. Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells. Dev. Biol. 286:574-586, 2005.
Miller, S.M., Roussi, P., Daly, M.B., Buzaglo, J.S., Sherman, K., Godwin, A.K., Balshem, A., Atchison, M.E. Enhanced counseling for women undergoing BRCA1/2 testing: impact on subsequent decision making about risk reduction behaviors. Health Educ. Behav. 32:654-667, 2005.
Yang, W.L., Godwin, A.K., Xu, X-X. Tumor necrosis factor-alpha-induced matrix proteolytic enzyme production and basement membrane remodeling by human ovarian surface epithelial cells: molecular basis linking ovulation and cancer risk. Cancer Res. 64:1534-1540, 2004.
Pinte, S., Guerardel, C., Deltour-Balerdi, S., Godwin, A.K., Leprince, D. Identification of a second G-C rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1. Oncogene 23:4023-4031 2004.
Altomare, D.A., Wang, H.Q., Skele, K.L., De Rienzo, A., Klein-Szanto, A.J., Godwin, A.K., Testa, J.R. AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene 23:5853-5857, 2004.
Stoyanova, R., Clapper, M.L., Bellacosa, A., Henske, E.P., Testa, J.R., Ross, E.A., Yeung, A. T., Nicolas, E., Tsichlis, N., Li, Y.S., Linehan, W.M., Howard, S., Campbell, K.S., Godwin, A.K., Boman, B., Crowell, J.A., Kopelovich, L., Knudson, A.G. Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations. Cancer Biol. Ther. 3:1313-1321, 2004.
Gupta, A., Godwin, A.K., Vanderveer, L., Lu, A.P., Liu, J. Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma. Cancer Res. 63:664-673, 2003.
Okamoto, I., Kenyon, L.C., Emlet, D.R., Mori, T. Sasaki, J-I., Hirosako, S., Ichikawa, Y., Kishi, H., Godwin, A.K., Yoshioka, M., Suga, M., Matsumoto, M., Wong, A.J. Expression of constitutively activated EGFRvIII in non-small cell lung cancer. Cancer Sci. 94:50-56, 2003.
Wagner Costalas, J., Itzen, M., Malick, J., Babb, J.S., Bove, B., Godwin, A.K., Daly, M.B. Communication of BRCA1 and BRCA2 results to at-risk relatives: a cancer risk assessment program's experience. Am. J. Med. Genet. 119:11-18, 2003.
Cesari, R., Martin, E.S., Calin, G.A., Pentimalli, F., Bichi, R., McAdams, H., Trapasso, F., Drusco, A., Shimizu, M., Masciullo, V., D'Andrilli, G., Scambia, G., Picchio, M.C., Alder, H., Godwin, A.K., Croce, C.M. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27. Proc. Natl. Acad. Sci. USA 100:5956-5961, 2003.
Prowse, A., Schultz, D.C., Guo, S., Vanderveer, L., Dangel, J. Bove, B., Cairns, P., Daly, M., Godwin, A.K. Identification of a novel splice acceptor site mutation in p16INK4A/p14ARF within a breast cancer, melanoma, neurofibroma-prone kindred. J. Med. Genet. 40:102-108, 2003.
Frolov, A., Chahwan, S., Ochs, M., Arnoletti, J.P., Pan, Z-Z., Favorova, O., Fletcher, J., von Mehren, M., Eisenberg, B., Godwin, A.K. Response markers and the molecular mechanisms of action of gleevec in gastrointestinal stromal tumors (GISTs). Mol. Cancer Ther. 2:699-709, 2003.
Capo-Chichi, C.D., Roland, I.H., Vanderveer, L., Bao, R., Yamagata, T., Hirai, H., Cohen, C., Hamilton, T.C., Godwin, A.K., Xu, X.X. Anomalous expression of epithelial differentiation determining GATA factors in ovarian tumorigenesis. Cancer Res. 63:4967-4977, 2003.
Martin E.S., Cesari R., Pentimalli, F., Yoder, K., Fishel, R., Himelstein, A.L., Martin, S.E., Godwin, A.K., Negrini, M., Croce, C.M. The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene. Proc. Natl. Acad. Sci. USA 100:11517-11522, 2003.
Burrows, J.F., Chanduloy, S., McIlhatton, M.A., Nagar, H., Yeates, K., Donaghy, P., Price, J. Godwin, A.K., Johnston, P.G., Russell, S.E.H. Altered expression of the septin gene, SEPT9, in ovarian neoplasia. J. Pathol. 201:581-588, 2003.
Dong, Y., Hakimi, M-A., Chen, X., Kumaraswamy, E., Cooch, N.S., Godwin, A.K., Shiekhattar, R. Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol. Cell 12:1087-1099, 2003.
Roland, I.H, Yang, W.L., Yang, D.H., Daly, M., Ozols, R.F., Hamilton, T.C., Lynch, H.T., Godwin, A.K., Xu, X.X. Loss of surface and cyst epithelial basement membranes and preneoplastic morphological changes in prophylactic oophorectomies. Cancer 98:2607-23, 2003.
Okamoto, I., Tsuiki, H., Kenyon, L.C., Godwin, A.K., Emlet, D.R., Holgado-Madruga, M., Lanham, I.S., Joynes, C.J., Vo, K.T., Guha, A, Matsumoto, M., Ushio, U., Saya, H., Wong, A.J. Proteolytic cleavage of CD44 adhesion molecule in multiple human tumors. Am. J. Pathol. 160:441-447, 2002.
Roberts, D., Williams, S.J., Cvetkovic, D., Weinstein, J.K., Godwin, A.K., Johnson, S.W., Hamilton, T.C. Decreased expression of retinol-binding proteins is associated with malignant transformation of the ovarian surface epithelium. DNA Cell Biol. 21:11-19, 2002.
Prowse, A.H., Vanderveer, L., Milling, S.W., Pan, Z.Z., Dunbrack, R.I., Xu, X.X., Godwin, A.K. OVCA2 is down-regulated and degraded during retinoid-induced apoptosis. Int. J. Cancer 99:185-192, 2002.
Yang, D-H., Smith, E.R., Cohen, C., Wu, H., Patriotis, C., Godwin, A.K., Hamilton, T.C., Xu, X.X. Molecular events associated with dysplastic morphologic transformation and initiation of ovarian tumorigenicity. Cancer 94:2380-2392, 2002.
Frolov, A., Prowse, A.H., Vanderveer, L., Bove, B., Wu, H., Godwin, A.K. DNA array-based method for detection of large rearrangements in the BRCA1 gene. Genes Chromosomes Cancer 35:232-241, 2002.
Andrulis, I.L., Anton-Culver, H., Beck, J., Bove, B., Boyd, J., Buys, S., Godwin, A.K., Hopper, J.L., Li, F. Neuhausen, S.L., Ozcelik, H., Peel, D., Santella, R.M., Southey, M., van Orsouw, N.J., Venter, D., Vijg, J., Whittemore, A., and the CFRBCS. Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations. Hum. Mutat. 20:65-73, 2002.
Antonyak, M.A., Kenyon, L.C., Godwin, A.K., James, D.C., Emlet, D.R., Okamoto, I., Tnani, M., Holgado-Madruga, M., Moscatello, D.K., Wong, A. Elevated JNK activation contributes to the pathogenesis of human brain tumors. Oncogene 21:5038-5046, 2002.
Capo-Chichi, C.D., Smith, E.R., Yang, D-H., Roland, I.H., Vanderveer, L., Cohen, C., Hamilton, T.C., Godwin, A.K., Xu, X-X. Dynamic alterations of the extracellular environment of ovarian surface epithelial cells in premalignant transformation, tumorigenicity, and metastasis. Cancer 95:1802-1815, 2002.
Smedberg, J., Smith, E.R., Capo-Chichi, C.D., Frolov, A., Yang, D.H., Godwin, A.K., Xu, X.X. Ras/MAPK pathway confers basement membrane dependence upon endoderm differentiation of embryonic carcinoma cells. J. Biol. Chem. 277:40911-40918, 2002.
Pan, Z.Z, Bruening, W. Giasson, B.I., Lee, V.M., Godwin, A.K. Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemoterapy drug-induced apoptosis by modulating MAPK pathways. J. Biol. Chem. 277:35050-35060, 2002.
Broccoli, D., Godwin, A.K. Telomere length changes in human cancer. (From Methods in Molecular Medicine, vol. 68: Molecular Analysis of Cancer. Edited by J. Boultwood and C. Fidler. Humana Press Inc., Totowa, NJ.) Methods Mol. Med. 68:271-278, 2002.
Bove, B, Dunbrack, R., Godwin, A.K. BRCA1, BRCA2, and Hereditary Breast Cancer. Breast Cancer: Prognosis, Treatment and Prevention. Edited by J. Pasqualini. Marcel Dekker Inc., Publisher, Chapter 19, pp. 555-624, 2002.
Raftogianis, R.B., Godwin, A.K. The impact of protein interaction technologies on cancer biology and pharmacogenetics, In: Protein-Protein Interactions: A Molecular Cloning Manual. Edited by E. Golemis. The Cold Spring Harbor, pp. 15-36, 2002.
Prowse, A. Frolov, A., Godwin, A.K. The genetics of ovarian cancer. American Cancer Society Atlas of Clinical Oncology. B.C. Decker Inc., Publisher, pp. 49-82, 2003.
Ochs, M., Godwin, A.K. Introduction. Microarrays in Cancer (Supplement to BioTechniques), p. 1, 2003, Guest Editor.
Ochs, M., Godwin, A.K. Microarrays in cancer: research and applications. BioTechniques 34:4-15, 2003.
Frolov, A. Godwin, A.K., Favorova, O.O. Differential gene expression analysis by DNA microarrays technology and its application in molecular oncology. Mol. Biol. 37:1-12, 2003.
Ozols, R.F., Bookman, M., Connolly, D., Daly, M.B., Godwin, A.K. Schilder, R., Xu, X., Hamilton, T.C. Focus on epithelial ovarian cancer. Cancer Cell 5:19-24, 2004.
Pan, Z-Z., Godwin, A.K. Oncogenes. In: Encyclopedia of Molecular Cell Biology and Molecular Medicine. Edited by Meyers, R.A., Second Edition, Volume 9, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, pp. 435-495, 2005.
Bui, C.T., Nicolas, E., Sallmann, G., Chiotis, M., Lambrinakos, A., Rees, K., Trounce, I., Cotton, R.G.H., Hancock, L., Godwin, A.K., Yeung, A.T. Enzymatic and chemical cleavage methods to identify genetic variation. In: Molecular Diagnostics. Edited by Patrinos, G. and Ansorge, W., Elsevier Academic Press, Chapter 5, pp. 41-54, 2005.
Tarn, C. Godwin, A.K. Molecular research directions in the management of gastrointestinal sromal tumors. Current Treatment Options in Oncology 6:473-486, 2005.
Chen, X., Arciero, C., Godwin, A.K. BRCA1-associated complexes: New targets to overcome breast cancer radiation resistance. Expert Review of Anticancer Therapy 6:187-196, 2006.
Miller, S.M., Daly, M.B., Sherman, K.A., Fleisher, L., Buzaglo, J.S., Stanton, L., Godwin, A.K., Scarpato, J. Psychosocial processes in genetic risk assessment for breast cancer. III. Applications to Specific Genetic Conditions. In: Individuals, Families, and the New Era of Genetics: Biopsychosocial Perspectives. Edited by Miller, S.M., McDaniel, S.H., Rolland, J.S., Feetham, S.L., W.W. Norton & Company, Inc.: New York, NY, Chapter 10, pp. 274-319, 2006.
Tarn, C. Godwin, A.K. The molecular pathogenesis of gastrointestinal stromal tumors. Clin. Colorectal Cancer 6 Suppl 1:S7-S17, 2006.