Thomas C Hamilton, PhD

Senior Member
Medical Science Division


Thomas.Hamilton@fccc.edu
Phone: 215-728-2856
Fax:
Thomas C Hamilton, PhD



Recent Publications

In Press


Nikitin, A.Y., Hamilton, T.C. (2005) Modeling Ovarian Cancer in the Mouse. Research Advances in Cancer, in press.

2005


Roberts, D., Schick, J., Conway, S., Biade, S., Laub, P.B., Stevenson, J.P., Hamilton, T.C., O'Dwyer, P.J., Johnson, S.W. Identification of genes associated with platinum drug sensitivity and resistance in human ovarian cancer cells. Br. J. Cancer 92:1149-1158, 2005.

2004


Cvetkovic, D., Pisarcik, D., Lee, C., Hamilton, T.C., Abdollahi, A. Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer. Gynecol. Oncol. 95(3):449-455, 2004.

Nikitin, A.Y., Connolly, D.C., Hamilton, T.C. Pathology of ovarian neoplasms in genetically modified mice. Comp. Med. 54:26-28, 2004.

Ozols, R.F., Bookman, M.A., Connolly, D.C., Daly, M.B., Godwin, A.K., Schilder, R.J., Xu, X.-X., Hamilton, T.C. Focus on epithelial ovarian cancer. Cancer Cell 5:19-24, 2004.

Stewart, S.L., Querec, T.D., Ochman, A.R., Bao, R., Babb, J.S., Wong, T., Koutroukides, T., Pinnola, A.D., Klein-Szanto, A., Hamilton, T.C., Patriotis, C. Characterization of a carcinogenesis rat model of ovarian preneoplasia and neoplasia. Cancer Res. 64(22):8177-8183, 2004.

2003  

  
Abdollahi, A., Gruver, B.N., Patriotis, C., and Hamilton, T.C. (2003) Identification of epidermal growth factor-responsive genes in normal rat ovarian surface epithelial cells. Biochemical and Biophysical Research Communications, 307:188-197.

Abdollahi, A., Pisarcik, D., Roberts, D., Weinstein, J., Cairns, P., and Hamilton, T.C. (2003) LOT1 (PLAGL1/ZAC1), the Candidate Tumor Suppressor Gene at Chromosome 6q24-25, is Epigenetically Regulated in Cancer . J. Biol. Chem., 278(8):6041-6049.

Balkwill, F., Bast, R.C., Berek, J., Chenevix-Trench, G., Gore, M., Hamilton, T., Jacobs, I., Mills, G., Souhami, R., Urban, N., Orsulic, S., Smyth, J. (2003) Current research and treatment for epithelial ovarian cancer. A Position Paper from the Helene Harris Memorial Trust. Eur. J. Cancer 39(13):1818-1827.

Capo-chichi, C.D., Roland, I.H., Vanderveer, L., Bao, R., Yamagata, T., Hirai, H., Cohen, C., Hamilton, T.C., Godwin, A.K., and Xu, X.-X. (2003) Anomalous Expression of Epithelial Differentiation-determining GATA Factors in Ovarian Tumorigenesis. Cancer Res. 63:4967-77.

Connolly, D.C., Bao, R., Nikitin, A.Y., Stephens, K.C., Poole, T., Hua, X., Harris, S.S., Vanderhyden, B.C., and Hamilton, T.C. (2003) Female mice chimeric for the expression of the SV40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer. Cancer Res., 63:1389-1397.

Cvetkovic, D., Williams, S.J., and Hamilton, T.C. (2003) Loss of Cellular Retinol-Binding Protein 1 Gene Expression in Microdissected Human Ovarian Cancer. Clinical Cancer Res., 9:1013-1020.

Garson, K., Dub?, M., Macdonald, E.A., Hamilton, T.C., Brewster, A., and Vanderhyden, B.C. (2003) Generation of tumors in transgenic mice expressing the SV40 T antigen under control of OSP-1 (Ovarian Specific Promoter 1). J. Soc. Gynecol. Investig., 10:244-50.

Hamilton, T.C., Connolly, D.C., Nikitin, A.Y., Garson, K., and Vanderhyden, B.C. (2003) Translational Research in Ovarian Cancer: A Must. Int. J. of Gynecol. Cancer, 13:1-11.

Nikitin, A, Yu., Connolly, D.C., and Hamilton, T.C. (2004) Pathology of ovarian neoplasms in genetically modified mice. Comparative Medicine, 54:26-28.

Orsulic, S., Liu, J., and Hamilton, T.C. (2003) Ovarian Cancer Models: Present Status, Future Needs. E. J. Cancer, 39:1818-1827.

Ozols, R.F., Daly, M.B., Klein-Szanto, A., Hamilton, T.C., Bast, Jr., R.C., and Brewer, M.A. (2003) Specific Keynote: Chemoprevention of Ovarian Cancer: The Journey Begins. Gynecol. Oncol., 88(1):S59-S66.

Roland, I.H., Yang, W.-L., Yang, D.-H., Daly, M.B., Ozols, R.F., Hamilton, T.C., Lynch, H.T., Godwin, A.K., and Xu, X.-X. (2003) Loss of surface and cyst epithelial basement membranes and preneoplastic morphologic changes in prophylactic oophorectomies. Cancer 98(12):2607-2623.

Selvakumaran, M., Pisarcik, D.A., Bao, R., Yeung, A.T., and Hamilton, T.C. (2003) Enhanced Cisplatin Cytotoxicity by Disturbing the Nucleotide Excision Repair Pathway in Ovarian Cancer Cell Lines. Cancer Res.,63:1311-1316.

2002


Capo-Chichi, C.D., Smith, E.R., Yang, D.-H., Roland, I.H., Vanderveer, L., Cohen, C., Hamilton, T.C., Godwin, A.K., and Xu, X.-X. (2002) Dynamic alternations of the extracellular environment of ovarian surface epithelial cells in premalignant transformation, tumorigenicity, and metastasis. Cancer 95(8):1802-15.

Hu, L., Hofmann, J., Zaloudek, C., Ferrara, N., Hamilton, T., Jaffe, R.B. (2002) Vascular endothelial growth factor immunoneutralization plus Paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer. Am. J. Pathol. 161(5):1917-24.

Yang, D.-H., Smith, E.R., Cohen, C., Wu, H., Patriotis, C., Godwin, A.K., Hamilton, T.C., and Xu, X.-X. (2002) Molecular Events Associated with Dysplastic Morphological Transformation and Initiation of Ovarian Tumorigenicity. Cancer, 94(9):2380-2392.

Yang, D.-H., Smith, E.R., Roland, I.H., Sheng, Z., He, J., Martin, W.D., Hamilton, T.C., Lambeth, J.D., and Xu, X.-X. (2002) Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev. Biol., 251:27-44.