Richard R Hardy, PhD

Senior Member
Basic Science Division


Richard.Hardy@fccc.edu
Phone: 215-728-2463
Fax: 215-728-2412
Richard R Hardy, PhD


Recent Publications


2006

Hardy, R.R. B-1 B cell development. Brief reviews series, J. Immunol. 177:2749-2754, 2006.

Hardy, R.R. B-1 B cell development, selection, natural autoantibody and leukemia. Current Opinion in Immunology. 18:547-555, 2006.


Rumfelt, L.L., Zhou, Y., Rowley, B.M., Shinton, S.A., and Hardy, R.R. Lineage specification and plasticity in CD19- early B cell precursors. J. Exp. Med. 203: 675-687.

2005


Wen, L., Brill-Dashoff, J., Shinton, S.A. Asano, M., Hardy, R.R. Hayakawa, K. Evidence of marginal zone B cell positive selection in spleen. Immunity 23:1-12.

Wen, L., Shinton, S.A., Hardy, R.R., Hayakawa, K. Association of B-1 B cells with follicular dendritic cells in spleen. J. Immunol. 174:6918-6926.

Hardy, R.R., Hayakawa, K. Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes. 2005. Springer Semin Immunopathol. 26:363-75.

Tse, L.E., Lam, K.-P., Hogquist, K.A., Hippen, K.L., Liu, J., Shinton, S.A., Rodine, P.R., Vegoe, A.L., Schlissel, Hardy, R.R., M. Rajewsky, K., and Behrens, T.W. Basal immunoglobulin signaling activity maintains developmental stage in immature B cells. PLoS, 3:e82.

2004


Hardy, R.R., Wei, C.-J., Hayakawa, K. Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells. Immunol. Rev. 197:61-74.

Maier, H., Ostraat, R., Gao, H., Fields, S., Shinton, S.A., Medina, K.L., Ikawa, T., Murre, C., Singh, H., Hardy, R.R., and Hagman, J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol 5:1069-1077.

Hardy, R.R. and Shinton, S.A. Characterization of B lymphopoiesis in mouse bone marrow and spleen. in "B Cell Protocols", Methods in Molecular Biology, Humana Press. 271:1-24.

2003


Hayakawa, K., Asano, M., Shinton, S.A., Gui, M., Wen, L.-J., Dashoff, J., Hardy, R.R. Positive selection of anti-Thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J. Exp. Med. 197:87-99.

Hardy, R. R. Development of VH11+ B cells: a model for selection of B cells producing natural autoantibodies. Curr Dir Autoimmun 6: 196-211.

Hardy, R.R. B-lymphocyte development and biology. in Fundamental Immunology (W.E. Paul, ed.), 5th ed. Lippincott Williams and Wilkins.

Hardy, R.R. B cell commitment: deciding on the players. Current Opinion in Immunology. 15:258-265.

2002


Bichi, R., Shinton, S.A., Martin, E.S., Koval, A., Calin, G.A., Cesari, R., Russo, G., Hardy, R.R., Croce, C.M. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc. Natl. Acad. Sci. USA 99:6955-6960.

2001


Allman, D., Lindsley, R. C., DeMuth, W., Rudd, K., Shinton, S. A., and Hardy, R. R. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol 167: 6834-6840.

Gui, M., Li, J., Wen, L.-J., Hardy, R.R., Hayakawa, K. ?-chain influences but does not solely control autoreactivity of Va14J281T cells. J. Immunol. 167:6239-6246.

Hardy, R.R., Hayakawa, K. B cell development pathways. Ann. Rev. Immunol. 19:595-621.

Roederer, M. and Hardy, R. R. Frequency difference gating: a multivariate method for identifying subsets that differ between samples. Cytometry 45: 56-64.

The information in the below link is obtained from Pubmed.

Publications by Richard Hardy on Pubmed.