Our overall research program goals are to develop, evaluate, and disseminate innovative interventions to prevent and control cancer morbidity and mortality. Our current focus is on primary prevention of skin cancer, the most common form of human malignancy. We are conducting an intervention trial with college students, who as adolescents and young adults, tend to put themselves at risk for later skin cancer by exposing themselves to high levels of ultraviolet radiation (UV) and protecting their skin minimally. The current trial is testing several intervention approaches: 1) UV-detect photos, 2) motivational interviewing, and 3) education about UV-related skin damage. UV-detect photos show facial skin damage due to UV exposure not visible to the naked eye. Motivational interviewing is a counseling style that has been successfully used for addiction treatment and is now being used as an effective intervention for other risky health behaviors. College students will be followed over the course of a year to evaluate the impact of the interventions on self-reported exposure and protective behaviors such as tanning and sunscreen use and on objective changes in skin color as measured by spectrophotometry. If these interventions are successful, we hope to find ways to disseminate them to other settings and populations such as primary care clinics and high schools in order to help reduce cancer risk more broadly. We are also interested in interventions designed specifically for indoor tanners, smokers, and others at risk for cancer.