Sarah H. Lawrence, Ursula D. Ramirez, Lei Tang, Farit Fazliyez, Lenka Kundrat, George D. Markham, and Eileen K. Jaffe, Shape-shifting leads to small molecule allosteric drug discovery, Chem & Biol. 2008 (in press).
Jaffe EK, Stith L. ALAD Porphyria Is a Conformational Disease. Am J Hum Genet. 2007 80:329-37.
Tang L, Breinig S, Stith L, Mischel A, Tannir J, Kokona B, Fairman R, Jaffe EK. Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins). J Biol Chem. 2006 281:6682-90.
PMID: 16377642
Akagi R, Kato N, Inoue R, Anderson KE, Jaffe EK, Sassa S. delta-Aminolevulinate dehydratase (ALAD) porphyria: the first case in North America with two novel ALAD mutations.. Mol Genet Metab. 2006 87:329-36
PMID: 16343966
Jaffe EK. Morpheeins - a new structural paradigm for allosteric regulation. Trends Biochem Sci. 2005 30:490-7
PMID: 16023348
Tang L, Stith L, Jaffe EK. Substrate induced interconversion of protein quaternary structure isoforms. J Biol Chem. 2005 280:15786-93.
PMID: 15710608
Bollivar DW, Clauson C, Lighthall R, Forbes S, Kokona B, Fairman R, Kundrat L, Jaffe EK. Rhodobacter capsulatus Porphobilinogen Synthase, a High Activity Metal Ion Independent Hexamer. BMC Biochem. 2004 5:17
PMID: 15555082
Jaffe EK. The porphobilinogen synthase catalyzed reaction mechanism. Bioorg Chem. 2004 32:316-25.
PMID: 15381398
Breinig S, Kervinen J, Stith L, Wasson AS, Fairman R, Wlodawer A, Zdanov A, Jaffe EK. Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase. Nat Struct Biol. 2003 10:757-63.
PMID: 12897770
Jaffe EK. An unusual phylogenetic variation in the metal ion binding sites of porphobilinogen synthase. Chem Biol. 2003 10:25-34.
PMID: 12573695
Jaffe EK. Investigations on the metal switch region of human porphobilinogen synthase. J Biol Inorg Chem. 2003 8:176-84.
PMID: 12459913
Kundrat, L., Martins, J., Stith, L., Dunbrack, R.L. Jr., Jaffe, E.K. A structural basis for half-of-the-sites metal binding revealed in Drosophila melanogaster porphobilinogen synthase. J. Biol. Chem. 2003 278:31325-31330.
PMID: 12794073
Jaffe EK, Kervinen J, Martins J, Stauffer F, Neier R, Wlodawer A, Zdanov A. Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid. J Biol Chem. 2002 277:19792-9.
PMID: 11909869
Kervinen J, Jaffe EK, Stauffer F, Neier R, Wlodawer A, Zdanov A. Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity. Biochemistry. 2001 40:8227-36.
PMID: 11444968
Mitchell LW, Volin M, Martins J, Jaffe EK. Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase. J Biol Chem. 2001 276:1538-44.
PMID: 11032841
Jaffe EK, Martins J, Li J, Kervinen J, Dunbrack RL Jr. The molecular mechanism of lead inhibition of human porphobilinogen synthase. J Biol Chem. 2001 276:1531-7.
PMID: 11032836