Finnberg N., Klein-Szanto A.J.P., and El-Deiry W.S. TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J Clin. Invest. 118:111-123, 2008.
Huang Q., Gumireddy K., Schrier, M., le Sage C., Nagel R., Nair S., Egan D.A., Li A., Huang G., Klein-Szanto A.J., Gimotty P.A., Katsaros D., Coukos G., Zhang L., Puré E. and Agami R. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nature Cell. Biol. (in press).
Fu J., Fong K., Bellacosa A., Ross E. , Apostolou S., Bassi D., Jin F., Zhang J., Cairns P., Ibañez de Caceres I., Braunewell K., and Klein-Szanto A.J. VILIP-1 Downregulation in Non-Small Cell Lung Carcinomas: Mechanisms and Prediction of Survival. Plos One (in press).
Klein WM, Wu H., Klein-Szanto A., Tahan S. Increased Expression of Stem Cell Markers in Malignant Melanoma. Modern Pathol. 20:102-107, 2007.
Yu Y., Fan J., Rouzer C.A., Marnett L.J., Klein-Szanto A.J., FitzGerald G.A., and Funk C.D. Targeted cyclooxygenase gene (Ptgs) exchange reveals discriminant isoform functionality. J. Biol. Chem. 282:1498-1506, 2007.
Yeager N., Klein-Szanto A., Kimura S., and Di Cristofano A. Pten Loss in the Mouse Thyroid Causes Goiter and Follicular Adenomas: Insights into Thyroid Function and Cowden Disease Pathogenesis. Cancer Res. 67: 959-966, 2007.
Sauter E.R., Wagner-Mann, C., Ehya H., Klein-Szanto A.J. Biologic markers of breast cancer in nipple aspirate fluid and nipple discharge are associated with clinical findings. Cancer Det. Preven. 31:50-58, 2007.
Oyama K., Okawa T., Nakagawa H., Takaoka M., Andl C., Kim S., Klein-Szanto A., Herlyn M., El-Deiry W., and Rustgi A.K. AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture. Oncogene 26:2353-64, 2007.
Gumireddy K., Sun F., Klein-Szanto A.J., Gibbins J.M. , Saunders A., Schultz P.G., Huang Q. Disulfide Isomerase ERp5 Promotes Tumor Invasion and Metastasis by Activating ErbB2/Phosphoinositide-3 Kinase Pathways. Proceed. Natl. Acad. Sci. (USA) 104: 6696-6701, 2007.
López de Cicco R., Bassi D., Benavides F., Conti C.J., Klein-Szanto A.J.P. Inhibition of Proprotein Convertases: Approaches to Block Squamous Carcinoma Development and Progression. Molec Carcinog. 46:654-659, 2007.
Bassi D.E. and Klein-Szanto A.J.P. Carcinogen Induced Animal Models of Head and Neck Squamous Cell Cancer Curr. Prot. Pharmacol. 14:2, 2007.
Page R., Klein-Szanto A.J., Litwin S, Nicolas E., Al-Jumaily R., Alexander P., Godwin A., Ross E., Schilder R., and Bassi D.E. Increased expression of the pro-proteinconvertase furin predicts decreased survival in ovarian cancer. Cell. Oncol. 29: 289-299, 2007.
Okawa T., Michaylira C.Z., Kalabis J., Stairs D.B., Nakagawa H., Andl C., Johnstone C.N., Klein-Szanto A.J., El-Deiry W.S., Cukierman E., Herlyn M., and Rustgi A.K. The functional interplay between EGFR overexpression, hTERT activation and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes & Development 21: 2788–2803, 2007.
Macias E., Kim Y., Miliani de Marval P.L., Klein-Szanto A., and. Rodriguez-Puebla M.L. Cdk2 Deficiency Decreases ras/CDK4-Dependent Malignant Progression, but Not myc-Induced Tumorigenesis. Cancer Res. 67: 9713-9720, 2007.
Aggarwal P., Lessie M.D., Lin D.I., Pontano L., Gladden A.B., Nuskey B., Goradia A., Wasik M.A., Klein-Szanto A.J.P., Rustgi A. K., Bassing C.H., and Diehl J.A. Nuclear accumulation of cyclin D1 during S phase inhibits Cul4-dependent Cdt1 proteolysis and triggers p53-dependent DNA rereplication. Genes & Development 21:2908-2922, 2007.
Lin D.I., Barbash O., Suresh Kumar K.,. Weber J., Harper J.W., Klein-Szanto A.J., Rustgi A., Fuchs S.Y., and Diehl J.A. Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex. Molecular Cell 24:365-366, 2006.
Kim S., Nakagawa H., Navaraj A., Naomoto Y., Klein-Szanto A.J., Rustgi A.K. and El-Deiry W.S. Tumorigenic Conversion of Primary Human Esophageal Epithelial Cells Using Oncogene Combinations in the Absence of Exogenous Ras Cancer Res. 66: 10415-10424, 2006.
Wickborn C., Klein-Szanto A., Schlag P.M. and Braunewell K.H.Expression and prognostic significance of Visinin-like-Protein-1 in squamous cell carcinoma of the esophagus. Molec. Carcinogenesis 45: 572-581, 2006.
Yu Y., Fan J., Chen X., Dairong Wang D., Klein-Szanto A.,FitzGerald G., Funk C.D. Genetic model of selective COX2 inhibition reveals novel heterodimer signaling and thromboembolic risk. Nature Med 12: 699-704, 2006.
Bassi D.E., Lopez de Cicco, Cenna J., Cukierman E, and Klein-Szanto A PACE 4 Expression in Mouse Basal Keratinocytes Results in Basement Membrane Disruption and Acceleration of Tumor Progression. Cancer Res. 65: 7310-7319, 2005.
Amatangelo M.D., Bassi D.E., Klein-Szanto A., and Cukierman E.Stroma-derived 3-D Matrices are Necessary and Sufficient to Promote Desmoplastic Differentiation of Normal Fibroblasts. Amer. J.Pathol. 167:475-488,2005.
Bassi D.E., Fu J., Lopez de Cicco R. and Klein-Szanto A.J.P.Proprotein Convertases: "Master Switches" in the Regulation of Tumor Growth and Progression. Molec. Carcinogenesis 44:151-161, 2005.
Gonzalez Guerrico, A.M., Jaffer, Z.M., Page, R., Braunewell, K.H., Chernoff, J., Klein-Szanto, A.J.P. Visinin-like protein-1 is a potent inhibitor of cell adhesion and migration in squamous carcinoma cells. Oncogene 24:2307-2316, 2005.
Lopez de Cicco, R., Bassi, D.E., Zucker, S., Seidah, N.G., Klein-Szanto, A.J. Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin. Cancer Res. 65:4162-4171, 2005.
Yu, Y., Chen, X.S., Klein-Szanto, A., Fitzgerald, G.A., Funk, C.D. Differential platelet and parturition response from diminished prostaglandin levels in mice harboring a hypomorphic prostaglandin H synthase allele. J. Clin. Invest. 115:986-995, 2005.
Balsara, B., Pei, J., Mitsuuchi, Y., Klein-Szanto, A., Wang, H., Unger, M., Testa, J.R. Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis 25:2053-2059, 2004.
Chen, Y., Juncai, H., Boorman, D., Klein-Szanto, A., O'Brien, T.G. Therapy of murine squamous cell carcinomas with 2-difluoromethylornithine. J. Carcinog. 3:10, 2004.
Krassenstein, R., Sauter, E., Dulaimi, E., Battagli, C., Ehya, H., Klein-Szanto, A., Cairns, P. Detection of breast cancer in nipple aspirate fluid by hypermethylation. Clin. Cancer Res. 10:28-32, 2004.
Lopez de Cicco, R., Watson, J.C., Bassi, D.E., Litwin, S., Klein-Szanto, A.J.P. Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous carcinoma progression. Clin. Cancer Res. 10:4480-4488, 2004.
Purev, E., Cai, D., Miller, E., Swoboda, R., Mayer, T., Klein-Szanto, A., Marincola, F.M., Mick, R., Otvos, L., Wunner, W., Birebent, B., Somasundaram, R., Wikstrand, C.J., Bigner, D., DeMichele, A., Acs, G., Berlin, J.A., Herlyn, D. Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, DeltaEGF-R, and de2-7 EGF-R). J. Immunol. 173:6472-6480, 2004.
Stewart, S., Querec, T., Ochman, A., Gruver, B., Bao, R., Babb, J., Wong, T., Koutroukides, T., Pinnola, P., Klein-Szanto, A., Hamilton, T.C., Patriotis, C. Characterization of a carcinogenesis rat model of ovarian preneoplasia and neoplasia. Cancer Res. 64:8177-8183, 2004.
Takaoka, M., Harada, H., Andl, C.D., Oyama, K., Naomoto, Y., Dempsey, K., Klein-Szanto, A., El-Deiry, W., Grimberg, A., Nakagawa, H. Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factorbinding protein 3. Cancer Res. 64:7711-7723, 2004.
Bassi, D.E., Mahloogi, H., Lopez DeCicco, R., Klein-Szanto, A.J.P. Increased furin activity enhances the malignant phenotype of human head and neck cancer cells. Am. J. Pathol. 162:439-447, 2003.
Mahloogi H., Gonz?lez-Guerrico A., Lopez De Cicco R., Bassi D.E., Goodrow T., Braunewell K-H. and Klein- Szanto A.J.P. Overexpression of the calcium sensor VILIP-1 leads to a cAMP-mediated decrease of In Vivo and In Vitro growth and invasiveness of squamous cell carcinoma cells. Cancer Research 63:4997-5004, 2003.
Mercapide J, Lopez De Cicco R., Castresana J.S., and Klein-Szanto A.J.P. Stromelysin-1/Matrix Metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. Int. J. Cancer 106: 676-682, 2003.
Mahloogi, H., Bassi, D.E., Klein-Szanto, A.J.P. Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4. Carcinogenesis 23:565-572, 2002.
Mercapide, J., Lopez, R., Bassi, D.E., Castresana, J., Thomas, G., Klein-Szanto, A.J.P. Alpha-1 PDX inhibits astocytoma growth and invasiveness. Clin. Cancer Res. (Adv. In Brief) 8:1740-1746, 2002.
Daniel E.Bassi, Ricardo Lopez De Cicco, Haleh Mahloogi, Stanley Zucker , Gary Thomas, and Andres J.P. Klein-Szanto. Furin Inhibition Results in Absent or Decreased Invasiveness and Tumorigenicity of Human Cancer Cells. Proc. Natl.Acad. Sci. (USA) 98:10326-10331, 2001.