Chen, X., Wang, L., Fazlieva, R., Kruger, W.D. Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response. Hum. Mutat. 27:474-482, 2006.
Tang, B., Kadariya, Y., Murphy, M.E., Kruger, W.D. The methionine salvage pathway compound 4-methylthio-2-oxobutanate causes apoptosis independent of down-regulation of ornithine decarboxylase. Biochem. Pharmacol. 72:806-815, 2006.
Pei, J., Kruger, W.D., Testa, J.R. High-resolution analysis of 9p loss in human cancer cells using single nucleotide polymorphism-based mapping arrays. Cancer Genet. Cytogenet. 170:65-68, 2006.
Park, E.S., Oh, H.J., Kruger, W.D., Jung, S.C., Lee, J.S. Recombinant adeno-associated virus mediated gene transfer in a mouse model for homocystinuria. Exp. Mol. Med. 38:652-661, 2006.
Kadariya, Y., Nakatani, K., Nishioka, J., Fujikawa, T., Kruger, W.D., Nobori, T. Regulation of human methylthioadenosine phosphorylase gene by the CBF (CCAAT binding factor/NF-Y (nuclear factor-Y). Biochem. J. 387:175-183, 2005.
Jhee, K-H. and Kruger, W.D. The role of cystathionine b-synthase in homocysteine metabolism. Antioxid. Redox Signal. 7:813-822, 2005.
Wang, L., Chen, X., Tang, B., Hua, X., Klein-Szanto, A., Kruger, W.D. Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Hum. Mol. Genet. 14:2201-8, 2005.
Tang, B., Kruger, W.D., Chen, G., Shen, F., Lin, W.Y., Mboup, S., London, W.T., Evans, A.A. Hepatitis B viremia is associated with increased risk of hepatocellular carcinoma in chronic carriers. J. Med. Virol. 72:35-40, 2004.
van Slegtenhorst, M., Carr, E., Stoyanova, R., Kruger, W.D., Henske, E.P. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe. J. Biol. Chem. 279:12706-12713, 2004.
Singh, R.H., Kruger, W.D., Wang, L., Pasquali, M., Elsas, L.J., 2nd. Cystathionine b-synthase deficiency: effects of betaine supplementation after methionine restriction in B6-nonresponsive homocystinuria. Genet. Med. 6:90-95, 2004.
Wang, L., Jhee, K-H., Hua, X.., DiBello, P.M., Jacobsen, D.W., Kruger, W.D. Modulation of cystathionine b-synthase level regulates total serum homocysteine in mice. Circ. Res. 94:1318-1324, 2004.
Apostolou, S., Klein, J.O., Mitsuuchi, Y., Shetler J.N., Poulikakos, P.I., Jhanwar, S.C., Kruger, W.D., Testa, J.R. Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype. Oncogene 23:5032-5040, 2004.
Chen, X., Jhee, K.H., Kruger, W.D. Production of the neuromodulator H2S by cystathionine b-synthase via the condensation of cysteine and homocysteine. J. Biol. Chem. 279:52082-52086, 2004.
Subhi, A.L., Tang, B., Balsara, B.R., Altomare, D.A., Testa, J.R., Cooper, H.S., Hoffman, J.P., Meropol, N.J., Kruger, W.D. Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Clin. Cancer Res. 10:7290-7296, 2004.
Cheon, M.S., Bajo, M., Kim, S.H., Claudio, J.O., Stewart, A.K., Patterson, D., Kruger, W.D., Kondoh, H., Lubec, G. Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis. (Part II). Amino Acids 24:119-125, 2003.
Kruger, W.D., Wang, L., Jhee, K.H., Singh, R.H., Elsas, L.J. Cystathionine ?-synthase deficiency in Georgia (USA): Correlation of clinical and biochemical phenotype with genotype. Hum. Mutat. 22:434-441, 2003.
Subhi, A.L., Diegelman, P., Porter, C.W., Tang, B., Lu, Z.J., Markham, G.D., Kruger, W.D. The tumor suppressor gene MTAP regulates ornithine decarboxylase activity by production of downstream metabolites. J. Biol. Chem. 278:49868-49873, 2003.
Tang, B., Kruger, W.D., Chen, G., Shen, F., Lin, W.Y., M'Boup, S., London, W.T., Evans, A.A. Low-titer HBV viremia is associated with increased risk of HCC in chronic carriers. J. Med. Virol. 72:35-40, 2003.
Christopher, S.A., Melnyk, S., James, S.J., Kruger, W.D. S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine ?-synthase. Mol. Genet. Metab. 75:335-343, 2002.
Christopher, S.A., Diegelman, P., Porter, C.W., Kruger, W.D. Methylthioadenosine phosphorylase, a gene frequently co-deleted with p16cdkN2a/ARF, acts as a tumor suppressor in a breast cancer cell line. Cancer Res. 62:6639-6644, 2002.
Guttormsen, A.B., Ueland, P.M., Kruger, W.D., Kim, C.E., Ose, L., Folling, I., Refsum, H. Disposition of homocysteine in subjects heterozygous for homocystinuria due to cystathionine beta-synthase deficiency: relationship between genotype and phenotype. Am. J. Med. Genet. 100:204-213, 2001.
Nozaki, T., Shigeta, Y., Saito-Nakano, Y., Imada, M., Kruger, W.D. Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan haemoflaggelate, Trypanosoma cruzi. Isolation and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from Trypanosoma. J. Biol. Chem. 276:6516-6523, 2001.
Shan, X., Dunbrack, R.L., Christopher, S.A., Kruger, W.D. Mutations in the regulatory domain of cystathionine beta synthase can functionally suppress patient-derived mutations in cis. Hum. Mol. Genet. 10:635-643, 2001.
Strizheva, G.D., Carsillo, T., Kruger, W.D., Sullivan, E.J., Ryu, J.H., Henske, E.P. The spectrum of mutations in TSC1 and TSC2 in women with tuberous sclerosis and lymphangiomyomatosis. Am. J. Respir. Crit. Care Med. 163:253-258, 2001.
Kruger, W.D., Evans, A.A., Wang, L., Malinow, M.R., Duell, P.B., Anderson, P.H., Block, P.C., Hess, D.L., Graf, E., Upson, B. Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid. Mol. Genet. Metabol. 70:55-60, 2000.
Tang, B., Li, Y.N., Kruger, W.D. Defects in methylthioadenosine phosphorylase are associated with but not responsible for methionine-dependent tumor cell growth. Cancer Res. 60:5543-5547, 2000.
Shan, X., Dunbrack, R.L., Christopher, S.A., Kruger, W.D. Mutations in the regulatory domain of cysthathionine b-synthase can functionally suppress patient-derived mutations in cis. Hum. Mol. Genet. 10:635-643, 2001.
Nozaki, T., Shigeta, Y., Saito-Nakano, Y., Imada, M., Kruger, W.D. Characterization of transsulfuration and cysteine biosynthetic pathways in the protozoan haemoflaggelate, trypanosoma cruzi: solution and molecular characterization of cystathionine beta-synthase and serine acetyltransferase from trypanosoma. J. Biol. Chem. 276:6516-6523, 2001.
Guttormsen, A.B., Ueland, P.M., Kruger, W.D., Kim, C.E., Ose, L., Folling, I., Refsum, H. Disposition of homocysteine in subjects heterozygous for homocystinuria due to cystathionine beta-synthase deficiency: relationship between genotype and phenotype. Am. J. Med. Genet. 100:204-213, 2001.
Malinow, M.R., Duell, P.B., Williams, M.A., Kruger, W.D., Evans, A.A., Anderson, P.H., Block, P.C., Hess, D.L., Upson, B.M., Graf, E.E., Irvin-Jones, A., Wang, L. Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations. Lipids 36:S27-32, 2001.
Christopher, S.A., Melnyk, S., James, S.J., Kruger, W.D. S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine b-synthase. Mol. Genet. Metab. 75:335-343, 2002.
Christopher, S.A., Diegelman, P., Porter, C.W. and Kruger, W.D. Methylthioadenosine phosphorylase, a gene frequently co-deleted with p16cdkN2a/ARF, acts as a tumor suppressor in a breast cancer cell line. Cancer Res. 262:6639-6644, 2002.
Subhi, A.L., Diegelman, P., Porter, C.W., Tang, B., Lu, Z.J., Markham, G.D., Kruger, W.D. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. J. Biol. Chem. 278:49868-49873, 2003.
Kruger, W.D., Wang, L., Jhee, K.H., Singh, R.H., Elsas, L.J. Cystathionine b-synthase deficiency in Georgia (USA): Correlation of clinical and biochemical phenotype with genotype. Hum. Mutat. 22:434-441, 2003.