Arthur S Patchefsky, MD

Senior Member
Medical Science Division

Chariman, Department of Pathology


Arthur.Patchefsky@fccc.edu
Phone: 215-728-5390
Fax:


Recent Publications


In Press


Hughes, J., Young, N.A., Wilbur, D.C., Renshaw, A.A., Mody, D.R. Fine-Needle aspiration of pulmonary hamartoma: A common source of false-positive diagnoses in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Arch Pathol Lab Med (in press).

Kucher, C., Zhang, P.J., Pasha, T., Elenitsas, R., Wu, H., Ming, M., Elder, D.E., Xu, X. Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi. Am. J. Dermatopathol. (in press)

Meyers, M.O., Brown, T.A., Young, N., Giles, L.R., Sigurdson, E.R., Hoffman, J.P., Ross, E., Boraas, M.C., Eisenberg, B.L., Torosian, M.H. Sentinel lymph node metastasis in breast cancer. Is completion axillary dissection mandated in all patients? Breast J. (in press).

Patchefsky, A.S., Ehya, H., Wu, H. Localized diseases of the bronchi and lung. In Principles and Practice of Surgical Pathology and Cytopathology, Fourth Edition, edited by S. Silverberg. Churchill Livingstone, New York (in press).

Sauter, E.R., Ehya, H., Klein-Szanto, A., Wagner-Mann, C., MacGibbon, B. Fiberoptic ductoscopy findings in women with and without spontaneous nipple discharge. Cancer (in press).

Wu, H., Barusevicius, A., Babb, J., Klein-Szanto, A., Godwin, A., Elenitsas, R., Gelfand, J.M., Lessin, S., Seykora, J.T. Pleiotrophin expression correlates with melanocytic tumor progression and metastatic potential. J. Cutan. Pathol. (in press).

2004


Al-Saleem, T., Al-Mondhiry, H. Immunoproliferative small intestinal disease (IPSID); a model for mature B-cell neoplasms. Blood. Epub, Nov. 12, 2004.

Al-Saleem, T., Cairns, P., Dulaimi, E.A., Feder, M., Testa, J.R., Uzzo, R.G. The genetics of renal oncocytosis; a possible model for neoplastic progression. Cancer Genet Cytogenet. 52(1):23-28, 2004.

Cooper, H.S. Neoplasms of the intestine. In Sternberg's Diagnostic Surgical Pathology, Fourth Edition, edited by S.E. Mills. Lippincott Williams & Wilkins, Philadelphia, pp. 1543-1601, 2004.

Dulaimi, E., Hilinck, J., Ibanez de Caceres, I., Al-Saleem T, Cairns, P. Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients. Clin Cancer Res. 10:6189-6193, 2004.

Dulaimi, E., Ibanez de Caceres, I., Uzzo, R.G., Al-Saleem, T., Greenberg, R.E., Polascik, T.J., Babb, J.S., Grizzle, W.E., Cairns, P. Promoter hypermethylation profile of kidney cancer. Clin Cancer Res. 10:3972-3979, 2004.

Dulaimi, E., Uzzo, R.G., Greenberg, R.E., Al-Saleem, T., Cairns, P. Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel. Clin Cancer Res. 10(6);1887-1893, 2004.

Edwards, R., Ward, M.R., Wu, H., Medina, C.A., Brose, M.S., Volpe, P., Nussen-Lee, S., Haupt, H.M., Martin, A., Herlyn, M., Lessin, S.R., Weber, B.L. Absence of BRAF mutations in UV-protected mucosal melanomas. J. Med. Genet. 41(4):270-272, 2004.

Ibanez de Caceres, I., Battagli, C., Esteller, M., Herman, J.G., Dulaimi, E., Edelson, M.I., Bergman, C., Ehya, H., Eisenberg, B.L., Cairns, P. Tumor cell specific BRCA1 and RASSF1A hypermethylation in serum, plasma and peritoneal fluid from ovarian cancer patients. Cancer Res. 64:6476-6481, 2004.

Krassenstein, R., Sauter, E., Al-Saleem, E., Battagli, C., Ehya, H., Klein-Szanto, A., Cairns, P. Detection of breast cancer in nipple aspirate fluid by hypermethylation. Clin. Cancer Res. 10:28-32, 2004.

Mueller, T.J., Wu, H., Greenberg, R.E., Hudes, G., Topham, N., Lessin, S.R., Uzzo, R.G. Cutaneous metastases from genitourinary malignancies. Urology 63(6):1021-106, 2004.

Patchefsky, A.S. Nonneoplastic pulmonary disease. In Sternberg's Diagnostic Surgical Pathology, Fourth Edition, edited by S.E. Mills. Lippincott Williams & Wilkins, Philadelphia, pp. 1111-1172, 2004.

Pollack, A., DeSilvio, M., Khor, L.Y., Li, R., Al-Saleem, T.I., Hammond, M.E., Venkatesan, V., Lawton, C.A., Roach, M. 3rd, Shipley, W.U., Hanks, G.E., Sandler, H.M. Ki-67 staining is a strong predictor of distant metastasis and mortality for men with prostate cancer treated with radiotherapy plus androgen deprivation: Radiation Therapy Oncology Group Trial 92-02. J. Clin. Oncol. 22(11):2133-2140, 2004

Renshaw, A.A., Schulte, M.A., Plott, E., Dubray-Bernstein, B., Cobb, C.J., Lozano, R.L., Neal, M.H., Hughes, J.H., Young, N.A., Prey, M. Cytologic features of high-grade squamous intraepithelial lesion in ThinPrep Papanicolaou test slides: Comparison of cases that performed poorly with those that performed well in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology. Arch. Pathol. Lab. Med. 128:746-748, 2004.

Renshaw, A.A., Young, N.A., Birdsong, G.G., Styer, P.E., Davey, D.D., Mody, D.R., Colgan, T.J. Comparison of performance of conventional and ThinPrep gynecologic preparations in the College of American Pathologists Gynecologic Cytology Program. Arch. Pathol. Lab. Med. 128:17-22, 2004.

Sauter, E.R., Klein-Szanto, A., Ehya, H., MacGibbon, B. Ductoscopic cytology and image analysis to detect breast cancer. Cancer 101:1283-1292, 2004.

Sauter, E.R., Ehya, H., Schlatter, L., MacGibbon, L. Ductoscopic cytology to detect breast cancer. Cancer J. 10:33-41, 2004.

Subhi, A., Tang, B., Salsara, B., Altomare, D., Testa, J.K., Copper, H.S., Hoffman, J.P., Meropol, N.J, Kruger, W.D. Loss of methylthiodenosine phosphylase and elevated ornithine dicarboxylase is common in pancreatic cancer. Clin. Cancer Res. 10:7290-7296, 2004.

Upson, J.S., Stoyanova, R., Cooper, H.S., Patriotis, C., Ross, E.A., Boman, B., Clapper, M.I., Knudson, A.G., Bellacosa, A. Optimized procedures for microarray analysis of histologic specimens processed by laser capture microdissection. J. Cell Physiol. 201:366-373, 2004.

Wu, H., Barusevicius, A., Lessin, S.R. Granuloma annulare with a mycosis fungoides-like distribution and palisaded granulomas of CD68-Positive histiocytes. J. Am. Acad. Dermatol. 51(1):39-44, 2004.

Young, N.A., Bibbo, M., Buckner, S., Colgan, T., Prey, M. Non-neoplastic findings. In The Bethesda System for Reporting Cervical/Vaginal Cytologic Diagnoses, Second Edition, edited by D. Solomon and R. Nayar. Springer-Verlag, New York, pp. 21-56, 2004.

Young, N.A., Ehya, H. Grading follicular lymphoma. The Achilles heel of diagnosis by cytology. Acta Cytol. 48:117-118, 2004.

2003


Al-Saleem, T.I. Re: Lin and Gray - Immunoproliferative small intestinal disease. Am. J. Gastroenterol. 98:501, 2003.

Battagli, C., Uzzo, R.G., Dulaimi, E., Ibanez De Caceres, I., Krassenstein, R., Al-Saleem, T., Greenberg, R.E., Cairns, P. Promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients. Cancer Res. 63:8695-8699, 2003.

Chism, D.B., Hanlon, A.L., Troncoso, P., Al-Saleem, T., Horwitz, E.M., Pollack, A. The Gleason score shift: score four and seven years ago. Int. J. Radiat. Oncol. Biol. Phy. 56:1241-1247, 2003.

Ehya, H., Patchefsky, A. Bronchus-Associated Lymphoid Tissue (BALT) Lymphoma: Diagnosis by Fine Needle Aspiration Cytology and Flow Cytometry. Case Report and Review. Pathol. Case Rev. 8:267-274, 2003.

Ehya, H., Young, N. Cytologic approach to tumors of the tracheobronchial tree. Chest Surg. Clin. N. Am. 13:1-22, 2003.

Freedman, G.M., Anderson, P.R., Goldstein, L.J., Hanlon, A.L., Cianfrocca, M.E., Millenson, M.M., von Mehren, M., Torosian, M.H., Boraas, M.C., Nicolaou, N., Patchefsky, A.S., Evers, K. Routine mammography is associated with earlier stage disease and greater eligibility for breast conservation in breast carcinoma patients age 40 years and older. Cancer 98:918-925, 2003.

Moriarty, A.T., Young, N.A. The Four R's: Reactive/Repair, Reporting and Regulations. Diagn Cytopathol. 29:1-3, 2003.

Patchefsky, A.S. Chapter 25, In Diagnostic Surgical Pathology, Fourth Edition, Nonneoplastic Pulmonary Disease, edited by S.S. Sternberg, Lippincott Williams & Wilkins, Philadelphia, 2003.

Patchefsky, A., Burk, M. Chapter 1, Pathology of Ovarian Tumors. In ACS Atlas of Oncology. edited by A. Patchefsky, M. Burk, B.C. Decker, Inc., Ontario, Canada, 2003.

Patchefsky, A., Goldberg, M. Unusual Bronchial Tumors. In Chest Surgery Clinics of North America, edited by A. Patchefsky, M. Goldberg, W.B. Saunders, Philadelphia, 2003.

Pollack, A., DeSilvio, M., Khor, L., Li, R., Al-Saleem, T., Hammond, M., Venkatesan, V., Byhardt, R., Hanks, G.E., Roach, M., Shipley, W.U., Sandler, H.M. Ki-67 Staining is a strong predictor of patient outcome for prostate cancer patients treated with androgen deprivation plus radiotherapy: an analysis of RTOG 92-02. Int. J. Radiat. Oncol. Biol. Phys. S200-S201, 2003.

Uzzo, R.G, Cairns, P, Al-Saleem, T., Hudes, G., Haas, N., Greenberg, R.E., Kolenko, V. The basic biology and immunobiology of renal cell carcinoma: consideration for the clinician. Urol. Clin. North Am. 30:423-436, 2003.

Wu, H., Smith, M., Millenson, M.M., Nicolaou, N., Van Deerlin, V.M., Addya, K., Lessin, S.R., Al-Saleem, T. Contribution of flow cytometry in the diagnosis of cutaneous lymphoid lesions. J. Invest. Dermatol. 121(6):1522-1530, 2003.

Wu, H., Stanley, J.R., Cotsarelis, G. Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. J. Inv. Dermatol. 120:1052-1057, 2003.

Zhu, W., Qin, W., Ehya, H., Lininger, J., Sauter, E. Microsatellite changes in nipple aspirate fluid (NAF) and breast tissue from women with breast carcinoma or its precursors. Clin. Cancer Res. 9:3029-3033, 2003.

2002


Augsburger, J.J., Correa, Z.M., Schneider, S., Yassin, R.S, Robinson-Smith, T, Ehya, H., Trichopoulos, N. Diagnostic transvitreal fine needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category. Trans. Am. Ophthalmol. Soc. 100:225-232, 2002.

Duffy, K., Al-Saleem, T., Karbowniczek, M., Ewalt, D., Prowse, A., Henske, E.P. Mutational analysis of the von Hippel Lindau gene in clear cell renal carcinomas from Tuberous Sclerosis Complex patients. Modern Pathol. 15(3):205-210, 2002.

Frolov, A., Prowse, A.H., Vanderveer, L., Bove, B., Wu, H., Godwin, A.K. DNA array-based method for detection of large rearrangements in the BRCA1 gene. Genes Chromosomes Cancer 35(3):232-241, 2002.

Patchefsky, A. Nonproliferative and benign proliferative epithelial lesions. In Atlas of Breast Pathology, Chapter 6, edited by S. Silverberg. W.B. Saunders, Philadelphia, pp. 57-65, 2002.

Solomon, D. Davey, D., Kurman, R., Moriarty, A., O'Connor, D., Prey, M., Raab, S., Sherman, M., Wilbur, D., Wright, T., Young, N. The 2001 Bethesda System: Terminology for reporting results of cervical cytology. JAMA 287:2114-2119, 2002.

Wetherington, R.W., Cooper, H.S., Al-Saleem, T., Ackerman, D.S., Adams-McDonnell, R., Davis, W., Ehya, H., Patchefsky, A.S., Suder, J., Young, N.A. Clinical Significance of performing immunohistochemistry on cases with previous diagnosis of cancer coming to a national comprehensive cancer center for treatment or second opinion. Am. J. Surg. Pathol. 26:1222-1230, 2002.

Yang, D.H., Smith, E.R., Cohen, C., Wu, H., Patriotis, C., Godwin, A.K., Hamilton, T.C., Xu, X. Molecular events associated with dysplastic morphological transformation and initiation of ovarian tumorigenicity. Cancer 94(9):2380-2392, 2002.

Wu, H., Eleinstsas, R., Zhang, P., Elder, D.E. Merkel cell carcinoma. In Endocrine Pathology, Chapter 11, edited by Li, Volsi, and Asa. W.B. Saunders, Philadelphia, PA, 2002.

Young, N.A. Back to the negative pap test: Behind the scenes at Bethesda 2001. Diagn. Cytopathol. 26:207-208, 2002.

Young, N.A., Mody, D.R., Davey, D.D. Misinterpretation of normal cellular elements in fine needle aspiration biopsies. Observations from the College of American Pathologists Interlaboratory Comparison Program in Non-Gynecologic Cytology. Arch. Pathol. Lab. Med. 126:670-675, 2002.

Young, N.A., Mody, D.R., Davey, D.D. Diagnosis and subclassification of breast carcinoma by fine needle aspiration biopsy: Results of the Interlaboratory Comparison Program in Non-Gynecologic Cytopathology. Arch. Pathol. Lab. Med. 126:1453-1457, 2002.

Zimmerman, R.L., Burke, M., Young, N.A., Solomides, C.C., Bibbo, M. Diagnostic utility of Glut-1 and CA 15-3 for discriminating adenocarcinoma from hepatocellular carcinoma in liver tumors biopsies by fine needle aspiration. Cancer Cytopathol. 96:53-57, 2002.

Zimmerman, R.L., Das, K.M., Bruke, M.A., Young, N.A., Solomides, C.C., Bibbo, M. The clinical utility of the CAS-1 monoclonal antibody in identifying adenocarcinoma of the colon metastatic to the liver in fine needle aspiration tissue. Cancer 96:(6):370-373, 2002.

2001


Chao, C., Al-Saleem, T., Brooks, J.J., Rogatko, A., Kraybill, W.G., Eisenberg, B. Vascular endothelial growth factor and soft tissue sarcomas: tumor expression correlates with grade. Ann. Surg. Oncol. 3: 260-267, 2001.

Cooper, H.S., Everley, L., Chang, W-C., Pfeiffer, G., Lee, B., Murthy, S., Clapper, M.L. The role of mutant Apc in the development of dysplasia and cancer in the mouse colitis model of Dextran Sulfate Sodium-induced colitis. Gastroenterology 121:1407-1416, 2001.

Elias, P.M., Matsuyoshi, N., Wu, H., Lin, C., Wang, Z.H., Brown, B.E., Stanley, J.R. Desmoglein isoform distribution affects stratum corneum structure and function. J. Cell Biol. 153(2):243-249, 2001.

Honavar, S.G., Shields, J.A., Shields, C.L., Demirci, H., Ehya, H. Extramedullary plasmacytoma confined to the choroid. Am. J. Ophthalmol. 131:277-278, 2001.

Jordan, J.J., Hanlon, A.L., Al-Saleem, T., Greenberg, R.E., Tricoli, J.V. Loss of the short arm of the Y chromosome in human prostate carcinoma. Cancer Genet. Cytogenet. 124:122-126, 2001.

Pingpank, J.F., Hoffman, J.P., Ross, E.A., Cooper, H.S., Meropol, N.J., Freedman, G., Pinover, W., Le Voyer, T.E., Sasson, A.R., Eisenberg, B.L. Effect of pre-operative chemoradiation on surgical margin status of resected adenocarcinoma of the head of the pancreas. J. Gastrointest. Surg. 5:121-130, 2001.

Sasson, A.R., Fowble, B., Hanlon, A.L., Torosian, M.H., Freedman, G., Boraas, M., Sigurdson, E.R., Hoffman, J.P., Eisenberg, B.L., Patchefsky, A.S. Lobular carcinoma in situ increases the risk of local recurrence in selected patients with stages I and II breast cancer treated with conservative surgery and radiation. Cancer 91(10):1862-1869, 2001.

Sauter, E.R., Ehya, H., Mammen, A., Klein, G. Nipple aspirate cytology and pathologic parameters predict residual cancer and nodal involvement after excisional breast biopsy. Br. J. Cancer 85:1952-1957, 2001.

Shields, J.A., Shields, C.L., Ehya, H. Lung cancer diagnosed by fine needle biopsy of the optic disc. Retina 21:665-666, 2001.

von Mehren, M., Arlen, P., Gulley, J., Rogatko, A., Cooper, H.S., Meropol, N.J., Alpaugh, K., Davey, M., McLaughlin, S., Beard, M.T., Tsang, K.Y., Schlum, J., Weiner, L.M. The influence of granulocyte macrophage colony stimulating factor and prior chemotherapy on the immunological response to vaccine (ALVA-CEA B7, 1) in patients with metastatic cancer. Clin. Cancer Res. 7:1181-1191, 2001.

Wu, H., Elitsas, R. Malignant nodular hidradenoma in a patient with neurofibromatosis type 1: a case report and review of the literature. Cutis 68:273-278, 2001.

Zimmerman, R.L., Burke, M., Young, N.A., Solomides, C.C., Bibbo, M. Diagnostic value of hepatocyte paraffin 1 antibody to discriminate hepatocellular carcinoma from metastatic carcinoma in fine needle aspirate biopsies of the liver. Cancer 93:288-291, 2001.