Jeffrey R Peterson, PhD

Associate Member
Basic Science Division


Jeffrey.Peterson@fccc.edu
Phone: 215-728-3568
Jeffrey R Peterson, PhD


Recent Publications

2007

Eswaran, J., Lee, W.H., Debreczeni, J.E., Filippakopoulos, P., Turnbull, A., Federov, O., Deacon, S.W., Peterson, J.R., Knapp, S. Crystal structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. Structure 15:201-213, 2007.

2006


Pelish, H.E., Peterson, J.R., Salvarezza, S.B., Rodriquez-Boulan, E., Chen, J.L., Stamnes, M., Macia, E., Feng, Y., Shair, M.D., Kirchhausen, T. The small molecule secramine inhibits Cdc42 dependent functions in cells and Cdc42 activation in vitro. Nat. Chem. Biol. 2:39-46, 2006.

Peterson, J.R., Lebensohn, A.M., Pelish, H.E., Kirschner, M.W. Biochemical suppression of small molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem. Biol. 13:443-452, 2006.

Peterson, J.R., Chernoff, J. Src transforms in a Cool way. Nat. Cell Biol. 8:905-907, 2006.

2005


Perlman, Z.E., Bock, J.E., Peterson, J.R., Lokey, R.S. Geometric diversity through permutation of backbone configuration in cyclic peptide libraries. Bioorg. Med. Chem. Lett. 15:5329-5334, 2005.

2004


Peterson, J.R., Bickford, L.C., Morgan, D., Kim, A.S., Ouerfelli, O., Kirschner, M.W., Rosen, M.K. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat. Struct. Mol. Biol. 11:747-755, 2004.

Peterson, J.R., Golemis, E.A. Autoinhibited proteins as promising drug targets. J. Cell. Biochem. 93:68-73, 2004.

2002


Peterson, J.R., and Mitchison, T.J. (2002). Small molecules - Big impact: A history of chemical inhibitors and the cytoskeleton. Chem. Biol. 9(12): 1275-1285.

2001


Peterson, J.R., Lokey, R.S., Mitchison, T.J. and Kirschner, M.W. (2001). A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc. Natl. Acad. Sci. USA 98: 10624-10629.