Fang, M, Sigal, LJ Direct CD28 costimulation is required for CD8+ T cell-mediated resistance to an acute viral disease in a natural host. J. Immunol. 2006; 177:8027-8036.
Fang M, Cheng H, Dai Z, Bu Z, Sigal LJ. Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host. Virology. 2006 Feb 5;345(1):231-43.
Fang M, Sigal LJ. Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus. J Immunol. 2005 Nov 15;175(10):6829-36.
Shen L, Sigal LJ, Boes M, Rock KL. Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity. 2004 Aug;21(2):155-65.
Ramirez MC, Sigal LJ. The multiple routes of MHC-I cross-presentation. Trends Microbiol. 2004 May;12(5):204-7.
Norbury, C. C. & Sigal, L. J. Cross priming or direct priming: is that really the question? 15, Curr Opin Immunol. 2003 Feb;15(1):82-8.
Serna, A., Ramirez, M.C., Soukhanova, A., Sigal, L.J. Cutting Edge: Efficient MHC class I cross-presentation during early vaccinia infection requires the transfer of proteasomal intermediates between antigen donor and presenting cells. J. Immunol. 171:5668-5672, 2003.
Ramirez, M. C. & Sigal, L. J. Macrophages and Dendritic Cells Use the Cytosolic Pathway to Rapidly Cross-Present Antigen from Live, Vaccinia-Infected Cells. J Immunol 169, 6733-6742 (2002).
Crotty, S., Hix, L., Sigal, L. J. & Andino, R. Poliovirus pathogenesis in a new poliovirus receptor transgenic mouse model: age-dependent paralysis and a mucosal route of infection. J Gen Virol 83, 1707-20 (2002).
Chang, J., Sigal, L. J., Lerro, A. & Taylor, J. Replication of the Human Hepatitis Delta Virus Genome Is Initiated in Mouse Hepatocytes following Intravenous Injection of Naked DNA or RNA Sequences. J Virol 75, 3469-73. (2001).
*Sigal, L. J. & Rock, K. L. Bone marrow-derived antigen-presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and - independent pathways of antigen presentation. J Exp Med 192, 1143-1150 (2000).
*Sigal, L. J., Crotty, S., Andino, R. & Rock, K. L. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. Nature 398, 77-80 (1999).
* Represents work carried out prior to L.J.S. joining FCCC
The information in the below link is obtained from Pubmed.
